FAMILY HISTORY. Up to 15% of pancreatic cancers are believed to be inherited. The risk of developing pancreatic cancer increases by 2-3 times if a person’s first degree relatives (mom, dad, brother, sister, or child) had pancreatic cancer. The risk increases with the greater number of family members affected.
GENETICS. Inherited genetic mutations have been linked to an increased risk of pancreatic cancer. Some of these genes are also responsible for breast and ovarian cancer, and melanoma. Some of these hereditary conditions are as follows:
- Familial adenomatous polyposis (FAP)
- Familial malignant melanoma and pancreatic cancer (FAMM-PC)
- Hereditary breast and ovarian cancer (HBOC) syndrome
- Li-Fraumeni syndrome
- Lynch syndrome
- Peutz-Jeghers syndrome